The bolts are the same (at least according to the parts numbers) but the mount they go into looks different between the passenger and driver’s side. The metal on the passenger side bushing looks thicker and the rubber around it thinner. I would think that combination would be more resistant to movement under load. However, that’s just speculation on my part. TMac would be the person who would likely know better than I would about what if any difference that would make.
Visually, there is a definite difference between the LH isolator on the single bolt models than the same LH isolator in the twin bolt models. But without information about the durometer (equalling flex) of the bushings, it's impossible to make any kind of accurate assumption. What I can say is that the off-center single bolt subframe even if the bushing had less flex is very suspect. It doesn't take an engineer to visualize that an off center mount (even if using a more robust isolator) is going to cause the RH side to raise in response to high torque situation which will exacerbate wear on the isolator and mounting bolt, and "tweak" the alignment of the half shafts, and the driveshaft.
We will probably never know what was happening at Ford or its suppliers, but I can say this- the fact that the 4 bolt subframes have reappeared on the recent builds is a "mea culpa"- or "my fault" from Ford. Having seen many different high performance IRS systems in the past, though I'm not a Ford expert, I don't remember any that connected into the rear diff cover, let alone used a single offset bolt to limit the differential rotation.